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For example, the quantitative contribution of the lactate shuttle likely varies by brain region and neural activity, and the interplay between its roles as an energy substrate and a signaling molecule (e.g., in epigenetic regulation) is poorly defined

Furthermore, research has revealed that primary CBD metabolites, particularly 7-OH-CBD and 7-COOH-CBD, can impact neural stem cells and potentially contribute to cytotoxicity or enzyme inhibition, leading to prolonged exposure (Latham et al