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As serum homocysteine (Hcy) and methylmalonic acid levels were identified as predictive factors for severe toxicity caused by pemetrexed, patients now receive vitamin B12 (B12) and folic acid (FA) supplementation before pemetrexed-containing chemotherapy [4]

872 Grigolo et al

On the basis of this finding, we queried for conformational rearrangements of CRBN that might stabilize its interaction with ENL by superimposing every reported structure of CRBN bound to a molecular glue in the closed conformation (Fig