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Voehringer DW

Animals were exposed to a gas mixture of 5% O 2 and 95% N 2 (mixed by volume) for 20 min to induce global hypoxia

The relationship is simple: adding more liquid lowers concentration, which increases the draw volume for the same target amount

Further, as explained in the CY 2025 PFS proposed rule (89 FR 61952), in a report analyzing the root causes of drug shortages between 2013 and 2017, FDA found that more than 60 percent of drug shortages were the result of manufacturing or product quality issues, and providing a full waiver of the rebate amount in situations that may be within a manufacturer's control could be perceived as rewarding manufacturers for poor quality management