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Another option for large pituitary tumors is radiation therapy, which is expensive ($3,000 to $5,000 in the Los Angeles area) and can have adverse side effects such as skin and hair loss, hearing loss, or problems with tear production in the eyes

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Efficacy and safety of setmelanotide, an mc4r agonist, in individuals with severe obesity due to lepr or pomc deficiency: single-arm, open-label, multicentre, phase 3 trials

[1] ALCAR modulates phospholipid metabolism and synaptic morphology while enhancing synthesis of neurotrophic factors and neurotransmitters