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In further embodiments, the invention encompasses a method of treating an NNMT-expressing cancer such as glioblastoma, by administering a therapeutically effective amount of one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa

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"Several liver diseases like acute hepatitis, cirrhosis, hepatocellular carcinoma and metastatic liver disease can also be accompanied by an increase in circulating cobalamin," according to the aforementioned researchers

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