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Middle East J

Mechanistically, PA reduces the expression of GPX4 and heat shock factor 1 and regulates the transcription of genes related to iron metabolism (such as FTH, TFR1, and SLC40A1), causing iron homeostasis imbalance, while GPX4 overexpression reverses PA-induced ferroptosis in cardiomyocytes

It typically begins with noticeable menstrual irregularities and concludes 12 months after the final menstruation, most commonly occurring between the ages of 40 and 55, although it may start as early as the mid-30s in some women (2)