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In the case of glucocorticoids, both excess (Cushings syndrome) and insufficiency (Addisons disease) contribute to oxidative stress through a variety of mechanisms, such as decreased antioxidant defenses, increased reactive oxygen species (ROS) generation, and impaired mitochondrial function, which ultimately results in chronic inflammation

Aust J Gen Pract 48(8):516519 Rhee MK et al (2024) Bacterial keratitis preferred practice Pattern

Trayhurn, P

GSH is also the precursor of phytochelatins (PCs) and the substrate of glutathione S-transferase (GST), which plays an important role in the resistance of plants to heavy metal toxicity [15]