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Intracellular signal pathways are involved in numerous biological processes and have also been demonstrated to be intimately linked to the development of drug resistance

Pouso MR, Melo BL, Gonalves JJ, Louro RO, Mendona AG, Correia IJ, et al

Furthermore, steroids like progesterone and estrogen have protective roles in terms of reducing oxidative stress, edema, and inflammation, besides preventing apoptosis and maintaining homeostasis