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Glucuronidation is also the principal mechanism through which steroid hormones, particularly oestrogens such as oestradiol, are broken down and excreted

The duration of semaglutide therapy is generally long-term

All participants would receive a standardized SSRI regimen and be randomized to adjunctive treatment with standardized extracts of Rhodiola rosea , Ginkgo biloba , Ashwagandha, or matched placebo, with triple blinding maintained across participants, clinicians, and outcome assessors

Only hairs in the anagen (growing) phase can be effectively targeted, as telogen (resting) hairs do not have mature pigment