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However, a few important questions remain to be answered for the effective clinical application of ferroptosis-focused treatments

Instead, activation energy barriers largely prevent their interaction and, thus, the approach to equilibrium (Floh, Enzyme-based redox signaling Signaling requires the reversible modification of a sensor and the subsequent activation of transducer and effector molecules (Figure 1)

Experimental treatments utilizing rapamycin, which activates autophagy, are under investigation to determine their potential to reduce atherosclerotic plaque burden in patients with cardiovascular disease [149]

10.1016/j.bmcl.2015.07.018 121 LeeJ.KangE