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Shown in the reduced (upper) and oxidized form (lower)

used a testicular islet allotransplanted model and revealed that the islet transplanted into the testis generates fewer CD8+ memory cells but induces more specific CD4+CD25+ Treg cells than that in a more conventional site (renal capsule) (95)

24 confirm this expectation by demonstrating that D-Nle-Cys-Ile-NH(CHFIG

one grade 1 CMV reactivation and mild CRS occurred, both manageable with tocilizumab ( Emerging therapeutic strategies for SLE extend beyond B cell depletion to target CD4 follicular helper T (Tfh) cells: E4BP4 inhibits Tfh differentiation by repressing BCL-6 transcription via recruitment of HDAC1 and EZH2, while impaired E4BP4 function and IFN-Idriven IL-21/IFN- production promote Tfh expansion and autoreactive B cell responses, supporting Tfh-directed CAR-T approaches ( Figure 4 )