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While -synuclein (-Syn), which is encoded by SNCA , is one of the fundamental components in the Lewy body, patients with SNCA mutants (A30P, E46K, H50Q, G51D, A53E, and A53T) or multiplications are really rare, characterized by autosomal dominant inheritance, widely distributed age of onset (from 19 to 81 years), and more rapid cognitive impairment (Rosborough et al., 2017)

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7 Carotid ultrasonography is a first-line method that uses sound waves to detect narrowing and distortion of the carotid artery due to plaque, as well as qualities of plaque, such as greater thickness, low plaque density, spotty calcification, and ulceration, that indicate greater vulnerability following a stroke or TIA