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Supplemental forms of several endogenous compounds may be important for preventing inflammation and damage, including S-adenosyl-L-methionine (SAMe) , glucosamine , and chondroitin sulfate

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mice given 1,2-dibromoethane in drinking-water at 103-117 mg/kg body weight per day for 15-17 months), inhalational exposure (mice and rats exposed at 10-40 ppm for 6-18 months) or skin administration (25-50 mg/mice, 3 times/week for 400-594 days) showed that 1,2-dibromoethane is carcinogenic to rats and mice, causing tumours in a variety of organs (both at the application site and distant sites, including the nasal cavity, lung, stomach, liver, skin, circulatory system and mammary glands)

Kula-Eversole et al., 2010