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Recycling 200, 107101

Beyond FSP1 there are therapeutic opportunities across the CoQ 10 oxidoreductase network While FSP1 currently has the strongest targetability signal, other CoQ 10 oxidoreductases may be therapeutically leveraged in defined genetic, metabolic or tissue contexts: (1) DHODH axis (mitochondrial defense in select contexts): DHODH connects pyrimidine synthesis to mitochondrial CoQ reduction, and in some settings, DHODH inhibition has been proposed to heighten ferroptosis sensitivity, especially in GPX4-low states

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Reactions were performed with 2 M nicotinamide and 30 M phosphoribosyl pyrophosphate (PRPP) in the presence of 1mM ATP and recombinant human NAMPT enzyme