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Conversely, in cancer stem cells, the CPT1A/c-Myc feedback loop activates the NRF2/GPX4 axis and downregulates ACSL4, thereby suppressing ferroptosis and potentially diminishing immunotherapeutic response (147)

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After blocking in 5% goat serum (Beyotime) for 30 min, the sections were incubated with antibodies against insulin, glucagon, fibronectin, desmin, and -SMA (Supplementary Table 2) at 4 C overnight