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Primary human hepatocytes (PHH) and Hep3B cells were employed to demonstrate knockdown efficiencies in vitro

Multiple organ protection models PLoS ONE Safety Data Safety Profile from Research Preclinical Safety Summary Toxicity (in vitro)None at research doses Dermal applicationExtensively safety-tested Cu deliveryPhysiological levels 50+ year researchNo serious concerns Regulatory & Risk Considerations FDA statusNot approved therapeutically Injectable human dataVery limited Copper overloadTheoretical at high doses Long-term systemicNot studied GHK-Cu has an excellent dermatological safety record in topical applications

G.Randall HughesA.HultgrenK

ProLUCID data were filtered through DTASelect to achieve a peptide false-positive rate below 5%