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T H 17 cells have been involved in the progression of many common autoimmune diseases, including psoriasis ( H 17 cells, plays critical roles in the pathogenesis of autoimmune diseases, targeting IL-17 alone with anti-IL-17 antibodies was not sufficient to improve clinical end points ( low RA T-cells are spontaneously biased to develop into IFN- and IL-17 producing pro-inflammatory T-cells, which play a central role for disease progression (59)

Sphingosine kinase (SphK) acts to generate sphingosine 1-phosphate (S1P) from sphingosine [65, 66]

Van Egeren D, Novokhodko A, Stoddard M, Tran U, Zetter B, Rogers M, et al

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