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This was followed by active clinical development for the treatment of several autoimmune diseases, and the first indication for which efgartigimod entered late-stage clinical trials was gMG, which was found to be ameliorated by intravenous (i.v.) delivery of efgartigimod in a pivotal, proof-of-concept, phase II study in 2019 [227]

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Deficiency concerns: Alcoholism intestinal and bariatric surgeries digestive disorders lack of intrinsic factor vegetarians Vegans who do not consume any animal products When you don't have enough folate and vitamin B12, deficiency can result in anemia, fatigue, irregular heartbeat, shortness of breath, hair loss, and pale skin with mouth sores