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The entry of cisplatin into the inner ear leads to the formation of inner ear cellular damage products (DAMPs), which, together with cisplatin, bind to toll-like receptors (TLRs) (Wang L

Among these, resveratrol, a polyphenol found in grapes, has been shown to activate SIRT1 and inhibit NF-B signaling, thereby reducing inflammation and oxidative stress (135)