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Stow SM, Causon TJ, Zheng X, Kurulugama RT, Mairinger T, May JC, et al

However, free metal-based nanozymes still face many challenges in complex physiological environments, such as being easily cleared by the reticuloendothelial system, having a limited retention time at the lesion site, being prone to agglomeration and loss of catalytic activity, and having potential biological toxicity

This device traps and accurately measures the gas generated in the enzymatic reaction solution well and the well adjacent to it, thus eliminating interference from the assay reagents on the enzyme and its substrate

JAMA 324 , 111 (2020)