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The analysis in the paper is very well done, says William Goddard

Semaglutide is a peptide, and peptides are sensitive to temperature, light, and bacterial contamination

In addition, GLP-1 promotes satiety and reduces energy intake by virtue of its neurotransmitter role in brainstem-hypothalamus pathways signaling satiety, and some long- acting GLP-1 RAs including semaglutide have shown cardiovascular risk reduction