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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial

[5] Tan B, Shi X, Zhang J, et al. Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization. Cancer Res. 2018;78(17):4929-4942. doi:10.1158/0008-5472.CAN-18-0152(IF:9.130)

These diverse actions underscore the importance of ChaC2 in maintaining cellular redox homeostasis and antioxidation mechanisms

Mechanistically, when tumor cells highly express SLC7A11, high Glu output could cause partial consumption of intracellular Glu and the feedback mechanism of the body drives cells to absorb more Gln and activate glutaminase (GLS) to convert it into Glu, resulting in a lack of Gln sensitivity in SLC7A11 high tumor [35] [36]