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Extended high-frequency audiometry (920 kHz) may detect early basal cochlear damage before standard frequencies are affected, providing a critical window for intervention ( Historically proposed schedules include baseline assessment, weekly monitoring during treatment, and follow-up at 1, 3, and 6 months post-treatment to detect delayed-onset or progressive losses ( Vestibular function assessment is frequently overlooked, despite well-recognized vestibulotoxicity risk posed by aminoglycosides as a class

Metabolic activation of specific natural products from herbal and dietary supplements is mediated by hepatic cytochrome P450 or intestinal bacteria, and generates chemical reactive/toxic metabolites that bind to cellular reduced glutathione or macromolecules, and form reactive metabolites-glutathione/protein/DNA adducts, and these protein/DNA adducts can result in toxicities

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A novel drug combination of Mangiferin and Cinnamic acid alleviates rheumatoid arthritis by inhibiting TLR4/NFB/NLRP3 activation-induced Pyroptosis