Such breeding efforts, among other targets, could be focused on producing feedstock with higher seed oil content through strategies such as metabolic engineering, increasing oil accumulation in non-seed vegetative tissues such as leaves, and improving overall resistance of the crop to abiotic and biotic stresses (Wan et al., 2017)
Accumulation of metabolites (such as trimethylamine) may increase the risk of side effects
Conclusion: NASH risk alleles were prevalent in the MAESTRO-NASH population and did not influence the treatment response to resmetirom Disclosures: Naga Chalasani: Madrigal: Consultant, Zydus, Ipsen, Pfizer, Merck, Altimmune, GSK: Consultant, Exact Sciences: Grant/Research Support, NIH: Grant/Research Support, Dominic Labriola: Nothing to Disclose, Rebecca Taub: Madrigal Pharmaceuticals: Employee, Madrigal Pharmaceuticals: Stock - publicly traded company, Madrigal Pharmaceuticals: Executive role, Quentin Anstee: AstraZeneca, Boehringer Ingelheim, Intercept.: Grant/Research Support, Alimentiv, Akero, AstraZeneca, Axcella, 89Bio: Consultant, Boehringer Ingelheim, Bristol Myers Squibb, Corcept: Consultant, Enyo Pharma, Galmed, Genfit, Genentech, Gilead, GlaxoSmithKl: Consultant, Hanmi, HistoIndex, Intercept, Inventiva, Ionis, IQVIA, Janss: Consultant, Madrigal, Medpace, Merck, Metadeq, NGMBio, North Sea T: Consultant, Novartis, Novo Nordisk, PathAI, Pfizer, Pharmanest: Consultant, Poxel, Prosciento, Resolution Therapeutics, Roche,: Consultant, Ridgeline Therapeutics, RTI, Shionogi, Terns: Consultant, Fishawack, Integritas Communications, Kenes,: Speaking and Teaching, Novo Nordisk, Madrigal, Medscape, Springer Healthcare: Speaking and Teaching, Elsevier Ltd: Royalties or patent beneficiary 2071 APPLYING THE METABOLIC DYSFUNCTION ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) NOMENCLATURE WITH NATURAL LANGUAGE PROCESSING IN A NATIONAL COHORT Binu John 1 Dustin Bastaich 2 Catherine Mezzacappa 3 Raphaella Ferreira 4 Austen Hentschel 5 Andres Samos 5 Nadim Mahmud 6 Tamar Taddei 3 David Kaplan 7 Marina Serper 8 Bassam Dahman 2 , 1 Miami VA and University of Miami, 2 Virginia Commonwealth University, 3 Yale University, 4 Larkin Community Hospital, 5 Florida International University, 6 Hospital of the University of Pennsylvania, 7 University of Pennsylvania, 8 University of Pennsylvania Health System Background: Although metabolic dysfunction-associated steatotic liver disease (MASLD) and MASLD with increased alcohol intake (MetALD) are identified as a separate clinical entities, tools to identify patients from electronic health records are lacking
It also helps to reduce inflammation, and supports the body's natural ability to fight off infection
