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Produced via solid-phase peptide synthesis

Although cytosolic CPS2 can produce a cytosolic pool of carbamoyl phosphate, CPS1 is a major rate-limiting enzyme in pyrimidine biosynthesis using nitrogen released via mitochondrial glutaminolysis 32

Moreover, lipid peroxidation products may contribute to hepatic dysfunction and the development of MASLD through mechanisms involving inflammation and the dysregulation of insulin signaling

Cook SF, Roberts JK, Samiee-Zafarghandy S et al , Population Pharmacokinetics of intravenous paracetamol (acetaminophen) in preterm and term neonates: model development and external evaluation