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Therapeutic benefits associated with the use of aminoglycoside have been restricted due to their high propensity to cause serious nephrotoxicity.101 Gentamicin, a strong cationic moiety, is mostly considered as prototype drug in studies of aminoglycosides associated nephrotoxicity as it is most nephrotoxic among this group.102 Gentamicin is believed to cause nephrotoxicity by its accumulation mainly in renal proximal tubular cells which results into lysosomal phospholipidosis mediated mitochondrial oxidative/nitrosative stress and subsequent inflammatory cascade and apoptosis.103 Shiffow and co-workers found that gentamicin cause severe degenerative granulation of renal cortex with marked lipid peroxidation

doi:10.1073/pnas.70.8.2439

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Lu YY, Fang CC, Hong CH, Wu CH, Lin YH, Chang KL, Lee CH