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Sublingual B12 was administered in laboratory conditions, where there was no dose omission, making it difficult to extrapolate real-world effects, where patient compliance may not be as good

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It should be noted that these studies measured total Cbl levels, but as previously mentioned, the biologically available form of Cbl, TCN2-Cbl, comprises only approximately 2030% of the total Cbl level, which may lead to a significant number of false negatives for clb deficiency