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Y., Chan, C

In preclinical studies, FXR agonists, such as obeticholic acid, have been approved for the treatment of primary biliary cholangitis and have shown promising therapeutic potential in intestinal diseases like IBD, although their side effects and tissue specificity require further optimization [474, 475]

Nonetheless, decreased L-tryptophan levels are correlated with indicators of impaired protein metabolism and IRS responses in MDD patients, including decreased serum zinc, transferrin, and high-density lipoprotein cholesterol (HDL-C) levels and elevated leukocyte counts and CD4 + /CD8 + T-cell ratios [68, 69]

The road less traveled: strategies to enhance the frequency of homology-directed repair (HDR) for increased efficiency of CRISPR/Cas-mediated transgenesis