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Feeling tired is an early sign of low glutathione

Hedgehog signaling suppresses Wnt signaling by regulating the expression of sFRP1 via its effector proteins, Gli1 and Gli2 (He et al., 2006

Based on the above mechanism, combined therapeutic strategies targeting the T cell-ferroptosis axis have shown clinical potential: radiotherapy synergizes with immunity, and radiotherapy-induced ATM activation synergistically inhibits SLC7A11 expression with IFN- released by CD8+ T cells, significantly increasing lipid peroxidation levels and thus significantly enhancing the therapeutic effect of ferroptosis (223)