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CCI injury in adult rats produced a 250 percent increase in OH production, which was sustained for 90 minutes (Marklund et al., 2001

To address these gaps, future research should prioritize larger scale multicenter randomized controlled trials with standardized protocols, adequately powered biomarker-guided RCTs with harmonised clinical endpoints plus GSH/GSSG, MDA/TBARS, SOD/CAT/GPx panels, head-to-head monotherapy vs

Acute high-intensity exercise also increases Tregs and FoxP3 + Tregs in the peripheral blood of adolescent swimmers (171), suggesting immune regulation may change post-exercise

219-221 Additionally, fucoidans have the capacity to reduce inflammation and oxidative stress