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Emerging evidence has underscored the neuroimmune role of T reg cells and T H 17 cells in the gutbrain axis, extending to neuropathological conditions such as AD, suggesting potential areas for future research

This agrees with a study conducted by Farahatet and colleagues, and Moin and colleagues who stated that skin types III-IV is a risk factor with negative therapeutic outcome in melasma treatment

Longo M, Paolini E, Meroni M, Duca L, Motta I, Fracanzani AL, Di Pierro E, Dongiovanni P (2021) -lipoic acid improves hepatic metabolic dysfunctions in acute intermittent porphyria: a proof-of-concept study

In a retrospective study of data from 127 adolescents treated with fumaric acid esters for up to 60 months, researchers found average improvements of up to 66% on standardized psoriasis severity scales