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While both sCSD and sB contain the 9092 amino acid sequence reported to regulate eNOS activity, sB may be more effective than sCSD and a better candidate for drug development because of its smaller size resulting in easier synthesis, improved tissue penetration, and a decreased potential for causing side effects including an immune response

Thioredoxins are low-molecular-weight proteins (1012 kDa) with a redox-active disulfide bond capable of transferring reducing equivalents to other protein targets via a dithiol exchange reaction (Fig

doi: 10.1016/j.diagmicrobio.2016.06.015 [DOI] [PMC free article] [PubMed] [Google Scholar] Sundnes KO, and Haimanot AT (1993)

Overexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosis