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Reader beware, this is a complex topic, but nonetheless, lets dig into this a bit more, with a look at how MTHFR relates to DNA methylation and the one-carbon pathway

Similarly, both in vivo feeding with a choline-rich diet and in vitro trimethylamine-N-oxidase (TMAO) stimulation increased TMAO-dependent NLRP3 inflammasome activation and expression of IL-1, IL6, TNF-, CXCL9, and CXCL10, supporting that NLRP3 is a key proteolytic activator in the macrophage response to a high choline and TMAO production (80) ( Figure 3 )

Importantly, research has indicated that BHMT also plays a significant role in methionine recycling in extrahepatic tissues, such as in breast cancer

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