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This process also triggers the release of proapoptotic factors ( Multiple research studies have indicated a correlation between the suppression of p53 and the avoidance of apoptosis by both malignant and pre-malignant cells, resulting in the beginning and the advancement of tumorigenesis (Yamamoto et al., 1999)

In addition, studies aiming at establishing dose-response relationships of (1) ATZ on CYP19A1 induction/activity, (2) curcumin on ATZ detoxification with ATZ plasma level as the outcome measure, and (3) curcumin on counteracting ATZs promoting effect on breast cancer development with breast tissue proliferation index as the endpoint would be extremely valuable in supporting curcumin as a mechanism-based antidote for ATZ exposure

Water soluble vitamins, like B12, can be tolerated at higher doses without adverse effects upon the body, and the National Academy of Medicine has not established an upper limit of Vitamin B12 intake

Regarding that a certain number of medicines in TCM has been shown to be anti-depressive [147]