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reported that severe MDD in hospitalized patients with no other concomitant medical condition is characterized by IRS activation, specifically T-cell activation with elevated serum levels of sIL-2R, an increased prevalence of measurable IL-2, increased in vitro-stimulated production of sIL-2R and interferon (IFN)-, and macrophage activation, including increased IL-1 and IL-6 production [15,16,17,18]