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Figure 1 The authors next explored which cell type is most sensitive to oxidative stress during the pathologic process of acute lung injury by detecting intracellular ROS levels with a fluorescent probe, and found that total ROS levels were significantly increased and the intracellular GSH/GSSG ratio was significantly decreased in macrophages in the hyperoxia-exposed group compared with the control group, and that Grx1 levels were significantly decreased in hyperoxia-exposed alveolar macrophages (AMs)

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At 8 months, only the NS-linked ETS capacity rate was further significantly reduced in mutants, as both N-linked and NS-linked OxPhos were already significantly reduced with age in controls (Fig

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