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Transforming growth factor (TGF)--activated kinase 1 (TAK1) activation requires phosphorylation of serine 412 by protein kinase A catalytic subunit (PKAC) and X-linked protein kinase (PRKX)

In this case the physician would administer a pulse steroid which is a few days of a high dose of intravenous steroid in order to maintain the oral dose or even taper off the oral dose

It is clinical education, not medical advice, and nothing here should be read as a treatment recommendation, protocol, or substitute for current clinical judgment and pharmacy guidance