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Unlike peptides that primarily influence appetite or hormone levels, 5-Amino-1MQ directly enhances cellular energy expenditure, promoting the breakdown of fat while preserving muscle mass

Omdat nicotinamide ook een tussenproduct is in de NAD+-salvage-route, staat NNMT op een kruispunt van de cellulaire methyl- en nicotinamidehuishouding

When NNMT depletes SAM in adipocytes, epigenetic regulation is disrupted potentially locking in gene expression patterns that favor energy storage over expenditure

Lipopolysaccharides (LPSs) from the outer membrane of Gram-negative bacteria may translocate through the intestinal border and cause subsequent systemic inflammation (247)