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Cerebellar Purkinje cells are insulin sensitive and functionally associated with peripheral insulin resistance We next investigated if metabolic and endocrine disruptions related to insulin-ATM signaling originating from the periphery may contribute to cerebellar degeneration and ataxia in A-T via the altered endocrine signals of insulin

The curvature index values were significantly lower at GSSG sites than at placebo sites in Weeks 6 and 10

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In biological research, cigarette smoke extract (CSE), which is made by either bubbling generated cigarette smoke through an aqueous solvent or eluting filter-trapped cigarette smoke particles, is frequently used to expose subjects to cigarette smoke