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doi: 10.1186/s13014-020-01654-9 103 WangJXWangZDuZLunG

2) NOXs (NADPH oxidases): These enzymes are specialized proteins that generate ROS as part of their normal function

Abnormal expression of these two families is primarily a result of gene dysregulation and translocation from organelles, which result in tumorigenesis mainly through two ways, the regulation of downstream molecular targets and the unsteady state of zinc homeostasis