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4.1 DNA-TG is a More Inclusive Measurement for Predicting Leukopenia in IBD As previously discussed, the majority of methods for measuring 6-TGNs fail to detect the influence of NUDT15 mutations

However, our literature searches showed that AFs interfere with DNA integrity, increase the secretion of pro-inflammatory factors, cytokines, and chemokines, inhibit DNA repair mechanisms, induce genomic instability, increase lipid peroxidation, induce DNA damage, cause tissue necrosis and organ failure, and dysregulate innate and adaptive immunity (290, 298300)

Similar to the in vitro hMOR binding and functional studies, mitragynine also exhibited the weakest antinociceptive effect (E max 17.3%) among the tested alkaloids at the highest dose tested (10 mg/kg, i.v.)

Which classes of glutathione S-transferases in each cellular system is directly responsible for involvement of aflatoxin-GSH conjugate formation What is the relationship between the efficiency of glutathione conjugation system and toxic action of aflatoxins in different cell systems