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This change not only suppressed Timp1 transcription but also activated MMP-9 , leading to mitochondrial damage and exacerbated oxidative stress (Mohammad and Kowluru, 2020

While all previous studies of amantadine as an antidyskinetic agent tested its symptomatic effect in PD patients who had established LIDs, the PREMANDYSK trial assessed if early adjunct therapy with amantadine has the potential to reduce dyskinesia risk in levodopa-treated early PD patients without LIDs [135]

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To view a copy of this licence, visit About this article Cite this article Kratzl, F., Urban, M., Pandhal, J