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Comm Meantal Health J 2019;55:15660

Some practitioners recommend 2 to 3 mg administered several times weekly rather than daily dosing

[DOI] [PMC free article] [PubMed] [Google Scholar] [30].Essex DW, Li M, Feinman RD, Miller A

Oral estrogenic preparations are considered to be pro-inflammatory because hepatic metabolism of 17-estradiol produces proinflammatory metabolites in higher concentrations than might be produced by more slowly absorbed transdermal products