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Pridopidine: a Sigma-1 receptor agonist in HD therapy Pridopidine, a sigma-1 receptor agonist (Grachev et al

Radix Angelica sinensis a component of the formula was found to exert antidepressant effect in animal model through upregulation of brain derived neurotrophic factor (BDNF) [48] which is found to be important role in protection against cognitive impairment associated with OSA [49]