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[46] contributed evidence pointing to APAP use as a cause of neurodevelopmental injury in susceptible babies and children [2]

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The gradient profile was as follows: 5% B from 0 to 0.5 min, 560% B from 0.5 to 11 min, 60100% B from 1111.1 min, maintained at 100% B until 12 min, then re-equilibrated at 5% B from 12.115 min

This convergence reinforces the validity of these integrated approaches, driving the docking of heparins, enabling a more accurate workflow, so overcoming the well-known uncertainties caused by the significant conformational flexibility of longer heparin chains