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Animals 14, 2156

SHMT2 is a proto-oncogene that is highly expressed in various human carcinogenesis (Usman et al., 2022)

Beyond their established effects on DNA methylation, SeNPs have been shown to modulate histone methylation by influencing the expression of specific histone methyltransferases (HMTs) such as EZH2, SETD7, and SUV39H2/KMT1B, and by altering the S-adenosylmethionine (SAM)/S-adenosylhomocysteine (SAH) ratio through the transsulfuration pathway