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Approximately 40% of plasma glutamine and uridine pools were labelled in tracer-infused mice, leading to ~2025% and ~15% labelling of glutamine and uridine, respectively, in non-neoplastic brain tissue and glioma xenografts (Fig

Therefore, although FH-deficient cells experience a chronic oxidative stress, GSH levels are not compromised in these cells

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In pursuit of elucidating the relationship between gene expression and phenotype severity, Pearson correlation analysis was selected to quantify the strength and direction of this association