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Health 25 (3), 325345 (2003)

Since LotA and AMSH-LP are highly specific DUBs for K6 and K63 chains, respectively, they can remove undesirable linkages synthesized by E3C

Serum markers of mitochondrial damage and death, including glutamate dehydrogenase (GDH), nuclear DNA (nDNA) and mtDNA have been investigated as clinically useful surrogate markers capable of indicating mitochondrial lysis following hepatocyte necrosis in APAP hepatotoxicity

Fasted mice or mice with low levels of endogenous GSH demonstrated increased severity of APAP-induced hepatic necrosis, whereas pretreatment of mice with precursors of GSH to elevate the endogenous GSH helped reduce liver damage [26]