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An analysis of extended survival in patients with amyotrophic lateral sclerosis treated with riluzole

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Cell 2007;130(3):427-39

But there is still a limitation in the clinical translation of such agents due to inefficient delivery to the eye and intraocular retention 8,14

Evolutionarily, the origin of RCD, in particular, apoptosis has been postulated to be associated with endosymbiosis, i.e., domestication of mitochondria [137,138,139]