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5 Conclusion In conclusion, we report a novel glutathione-responsive nanoplatform that integrates three complementary functional componentsSBA-15 mesoporous silica as a high-capacity carrier, enzalutamide covalently tethered to the silica via redox-sensitive disulfide linkages, and thiolated nitrogen-doped carbon dots (SNCDs) as stable fluorescent reporterstogether with folic-acid surface decoration for active tumor targeting

doi: 10.1016/j.pathophys.2013.11.010 110 IbrahimA

Microcomputed tomography (CT) and histomorphometric analysis Femura and tibiae obtained from mice were dissected free of soft tissue, fixed overnight in 10% neutral buffered formalin for 24 h, dehydrated in 70% ethanol for 3 days, and analyzed by a high resolution CT (SkyScan 1076 in-vivo CT, SKYSCAN) installed with softwares NRecon v1.6, CTan v1.9, and CTVol v2.0